General Information about the Course

Course Code:	DNT 113
Course Title:	Committee 3: Biological Regulation
Course Semester:	1. Semester / Fall
Course Credits:	Theoretical Practical Credit ECTS 6 2 7 4
Language of instruction:	EN
Prerequisite of the course:	No
Ders İş Deneyimini Gerektiriyor mu?:	No
Type of course:	Necessary
Level of course:	Bachelor TR-NQF-HE:6. Master`s Degree QF-EHEA:First Cycle EQF-LLL:6. Master`s Degree
Course Lecturer(s):	Prof. M.D. H. Yegane Güven (Biochemistry) / Asst. Prof. Hande Koçak (Medical Biology) / Prof. M.D. Tangül Müdok -- Asst. Prof. Türkân Sarıoğlu (Histology and Embryology) / Asst. Prof. Hasan Hüseyin Şahin (Physiology) / Asst. Prof. Cevdet Nacar (Biophysics)
Course Assistants:

Purpose and content of the course

Course Objectives:	To understand the mechanisms of intracellular regulation. To associate various chemical regulations with intracellular organelle ultrastructure. To comprehend macromolecular structure and biosynthesis. To understand metabolic control mechanisms. To know phenotypic variations (epigenetics) that are hereditary and not genetic.
Course Objective:	To know the mechanisms and control of transcription and translation in the cell. To comprehend active and inactive synthesis areas in nucleolus organelle where RNA synthesis from DNA is performed. To comprehend epigenetics and epigenome. To understand DNA and RNA sequencing and discuss its use in biotechnology, forensic medicine, and medical diagnosis. To learn about genetic treatments in diseases.
Mode of Delivery:	Face to face

Learning Outcomes

Knowledge (Described as Theoritical and/or Factual Knowledge.)

1) Students know the transcription mechanisms of RNA from DNA.

2) Students know the location of nucleolar synthesis, where the synthesis of rRNA from rDNA within cell ultrastructure is performed.

3) Students know the chemistry of intracellular free radicals and antioxidants.

4) Students know intracellular macromolecular synthesis pathways and control mechanisms

Skills (Describe as Cognitive and/or Practical Skills.)

1) Students discuss the regulation of the biological system

2) Students list the intracellular location of gene control mechanisms at the ultra-structural level.

3) Students lists antioxidants.

4) Students know the chemical structure and synthesis mechanisms of macromolecules.

Competences (Described as "Ability of the learner to apply knowledge and skills autonomously with responsibility", "Learning to learn"," Communication and social" and "Field specific" competences.)

1) Students exhibit responsibility and self-discipline.

2) Students have productive and questioning personalities.

3) Students use their mother tongue effectively, strive to use their foreign language.

4) Students can work independently and take responsibility.

Course Topics

Week	Subject
Related Preparation	Pekiştirme
10)	BIOCHEMISTRY: Biological Oxidations MEDICAL BIOLOGY: RNA transcription mechanism, RNA function HISTOLOGY- EMBRIOLOGY: Nucleolus BIOPHYSICS: Structure of Magnetic Resonance Device
11)	BIOCHEMISTRY: Free radicals, Antioxidants, Antioxidant Nutrients MEDICAL BIOLOGY: Genetic code, protein synthesis BIOPHYSICS: Ultrasonography
12)	BIOCHEMISTRY: Nucleic Acids and Protein Synthesis Laser Physics-1 MEDICAL BIOLOGY: Control mechanisms of gene expression at transcription and translation level BIOPHYSICS: Laser Physics-1
13)	BIOCHEMISTRY: Hormones and Biochemical Mechanisms of Action MEDICAL BIOLOGY: Epigenetics and Epigenome BIOPHYSICS: Laser Physics-2
14)	BIOCHEMISTRY: Lipids and their Biological Importance MEDICAL BIOLOGY: DNA and RNA sequencing with DNA replication/ Gene Therapy
References: Biochemistry: ** Wictor W. Rodwell, D. A. B., Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil. (2019). Harper'ın Resimli Biyokimyası (31 ed.). Güneş Tıp Kitabevi. ** Gürdöl, F. (2021). Tıbbi Biyokimya (5 ed.). Nobel Tıp Kitapevi. Tıbbi Biyoloji ve Genetik: ** Geçkil, H., Özmen, M., & Yeşilada, Ö. (2011). Moleküler Hücre Biyolojisi. Palmae yayıncılık. ** Klug, W. S., Cummings, M. R., Spencer, C. A., & Öner, C. (2011). Genetik kavramlar. Palme Yayıncılık. ** Allison, L. (2014). Temel Moleküler Biyoloji. Palme Yayınevi. Histology-Embriology: ** Junqueira, L. C. U., Carneiro, J., Aytekin, Y., & Solakoğlu, S. (2009). Temel histoloji: text & atlas. Nobel Tıp Kitabevleri. ** Mescher, A. (2015). Junqueira's Temel Histoloji Atlas Kitap. İstanbul: Nobel Tıp Kitabevleri Tic. Ltd. Şti. ** Demir, R. (2006). Histoloji ve Hücre Biyolojisi: Patolojiye Giriş. Palme Yayıncılık. ** Ross, M., & Pavlina, W. (2014). Histoloji Konu Anlatımı ve Atlas (6. Baskı). B. Baykal (Çev.), Ankara: Palme Yayıncılık. ** Yüncü, P. D. M. (2016). Genel Histoloji ve Genel Embriyoloj. Çukurova Nobel Tıp Kitapevi. ** Can, A. (2018). Yaşam Bilimlerinde A’dan Z’ye Mikroskopi. Ankara Nobel Tıp Kitapevi. Biophysics: ** Hüseyin OZAN TEKİN, M. D., Ali SALAR, Barış CAVLI, Mustafa Cantay GÖK. (2020). Manyetik Rezonans Görüntüleme Teknikleri ve Temel Prensipler. Kongre Kitapevi. ** Ahmet Fatih KOCAER, B. C., Birnur YILMAZ, Ceren ÖZTÜRK, Fatih BEŞEVLİ, Halil BOZKAYA, Hüseyin Ozan TEKİN, Miraç KAMIŞLIOĞLU, Murat DÜNDAR, Orhan OYAR, Türkan UZ İKİZCELİ. (2018). X Işınları Görüntüleme Teknikler. Kongre Kitapevi. ** Aydın, R. (2016). Lazer ve Tıp Uygulamaları. ODTÜ Yayıncılık.

Ders - Program Öğrenme Kazanım İlişkisi

No Effect	1 Lowest	2 Average	3 Highest

Ders Öğrenme Kazanımları	1	2	3	4	5	6	7	8	9	10	11	12
Program Outcomes
1) The normal, abnormal and pathological structures and functions related to oral and dental health in detail.
2) The basic and up-to-date knowledge required by the dentistry profession.
3) The integration of knowledge from different disciplines in the clinic phase and to put their knowledge into practice.
4) Applying knowledge in a holistic approach in professional practice.
5) Evaluating the accuracy, reliability and validity of the knowledge.
6) Showing a systematic approach to diagnosis.
7) Delivering optimum care for patients with correct diagnosis and treatment plan.
8) Conduct a clinical study or a project individually in the field of dentistry.
9) Take responsibility for the use of all technological tools used in dental treatment.
10) Take responsibility in planning and management of either routine applications or complex and unforeseen problems.
11) Participate in national and international academic studies by adopting lifelong learning, share and compare written, verbal and visual information with their colleagues.
12) Follow the evidence-based dentistry knowledge and use the up-to-date knowledge in professional practice within the framework of national values and country facts for the benefit of the society.
13) Use the information and communication technologies at the level required by the field of dentistry.
14) Take part and responsibilities in preventive programs at the social level, and ensure the protection and development of health by applying modern treatment methods with an approach that is patient-oriented, in line with human rights and compatible with the health economy.
15) Organize and implement social responsibility projects and activities.
16) Have proficiency in one foreign language at minimum B1 Level according to European Language Portfolio Global Scale, have written and oral communication skills and follow the developments in their field.
17) Apply the principle of entrepreneurship, business practices and processes with innovative technology in dentistry.
18) Are aware of the significance of ethical rules and legal responsibilities required by the profession.
19) Have knowledge about teamwork, leadership, risk management, patient safety, universality of social rights, social justice, quality management, personal development, environmental protection, occupational health and safety in the delivery and management of oral and dental healthcare services.
20) Implement the required practices in the clinic management, auxiliary personnel training, prevention methods from occupational diseases.

Course Teaching, Learning Methods

Q & A
Case Problem Solving/ Drama- Role/ Case Management
Laboratory
Quantitative Problem Solving
Fieldwork
Group Study / Assignment
Individual Assignment
WEB-based Learning
Internship
Practice in Field
Project Preparation
Report Writing
Seminar
Supervision
Social Activity
Occupational Activity
Occupational Trip
Application (Modelling, Design, Model, Simulation, Experiment et.)
Reading
Thesis Preparation
Field Study
Student Club and Council Activities
Other
Logbook
Interview and Oral Conversation
Research
Watching a movie
Bibliography preparation
Oral, inscribed and visual knowledge production
Taking photographs
Sketching
Mapping and marking
Reading maps
Copying textures
Creating a library of materials
Presentation

Evaluation System

Semester Requirements	Number of Activities	Level of Contribution
Attendance		% 0
Laboratory		% 0
Application		% 0
Practice Exam		% 0
Quizzes		% 0
Homework Assignments		% 0
Presentation		% 0
Project		% 0
Special Course Internship (Work Placement)		% 0
Field Study		% 0
Article Critical		% 0
Article Writing		% 0
Module Group Study		% 0
Brainstorming		% 0
Role Playing + Dramatizing		% 0
Out of Class Study		% 0
Preliminary Work, Reinforcement		% 0
Application Repetition etc.		% 0
Homework (reading, writing, watching movies, etc.)		% 0
Project Preparation + Presentation		% 0
Report Preparation + Presentation		% 0
Presentation / Seminar Preparation + Presenting		% 0
Oral examination		% 0
Midterms	1	% 40
Final	1	% 60
Report Submission		% 0
Bütünleme		% 0
Kanaat Notu		% 0
Committee		% 0
Yazma Ödev Dosyası		% 0
Portfolio		% 0
Take-Home Exam		% 0
Logbook		% 0
Discussion		% 0
Participation		% 0
total		% 100
PERCENTAGE OF SEMESTER WORK		% 40
PERCENTAGE OF FINAL WORK		% 60
total		% 100

Calculation of Workload and ECTS Credits

Activities	Number of Activities	Workload
Course Hours	5	40
Laboratory	5	10
Application
Practice Exam
Special Course Internship (Work Placement)
Field Work
Study Hours Out of Class
Article Critical
Article Writing
Module Group Study
Brainstorming
Role Playing + Dramatizing
Out-of-Class Study (Pre-study, Reinforcement, Practice Review, etc.)	5	40
Homework (reading, writing, watching movies, etc.)	3	9
Project Preparation + Presentation
Report Preparation + Presentation
Presentation / Seminar Preparation + Presenting
Oral examination
Preparing for Midterm Exams	7	14
MIDTERM EXAM (Visa)	1	1
Preparing for the General Exam	14	28
GENERAL EXAM (Final)	1	1
Participation
Discussion
Portfolio
Take-Home Exam
Logbook
Total Workload		143
ECTS (30 saat = 1 AKTS )		4