DENTISTRY (ENGLISH)
Bachelor TR-NQF-HE: Level 6 QF-EHEA: First Cycle EQF-LLL: Level 6

General Information about the Course

Course Code: DNT1002
Course Title: Basic Sciences Committees I (Committee 1-2-3-4-5)
Course Semester: 1. Semester / Fall
Course Credits:
Theoretical Practical Credit ECTS
8 3 10 22
Language of instruction: EN
Prerequisite of the course: No
Type of course: Necessary
Level of course:
Bachelor TR-NQF-HE:6. Master`s Degree QF-EHEA:First Cycle EQF-LLL:6. Master`s Degree
Course Lecturer(s): Asst. Prof. Sercan Doğukan Yıldız (Anatomy) Prof. H. Yegane Güven (Biochemistry) - Prof. A. Kaya Emerk (Biochemistry) Asst. Prof. Ezgi Gizem Berkay (Medical Biology) -- Asst. Prof. Türkân Sarıoğlu (Histology and Embryology) Asst. Prof. Hasan Hüseyin Şahin (Physiology), Lecturer Can Veysel Şoroğlu (Biophysics)

Purpose and content of the course

Course Objectives: 1-Understanding what molecules are the basis of life and why it is important for life. To have an idea about molecular evolution and to know the concept of chemical bonds and energy in living things on the systematic path to the human body structure. Name the microscopic techniques and types of microscopes used to observe the fine structures of cells and tissues from cell to human. Know the basic terms and concepts of human anatomy.
2-To know the development, structure and function of the cell and its sub-components. To evaluate the biochemical process of the cell.
3-To understand the mechanism of intracelluler regulation. To assaciate various chemical regulations with intracellular organelle ultrastructure. To comprehend macromolecular structure and biosynthesis. To understand metabolic control mechanisms. To know phenotypic variations (epigenetics) that are hereditary and not genetic.
4-To understand the transition to histological tissue organization within biological organization after biological regulation, classification of tissues and macro anatomy. To comprehend the laws of movement of biophysics within the organization related to movement. To know the chemistry of macromolecules that make up tissues. To understand physiology related to tissue stimulation.
5-To understand the first steps of reproduction in understanding human structure and function.
Course Objective: 1-To understand what chemical compounds are and why they are important for life. To learn the classification of hydrocarbons in inorganic and organic chemical structure. To identify aromatic and aliphatic molecules. To know heterocyclic compounds. To define the structure of nucleic acids in macromoleculer compounds synthesized by living cells. To know the methods and types of microscopes used in the observation and research of cells and tissues, to define basic anatomical terms, to define anatomical axes and planes.
2-To know the relationship between water and metabolism, the concept of pH and buffer. To comprehend cell membrane properties and associate them with ultra-structural morphology. To understand the chemical structure of the two main components of cell's genetic material (DNA and RNA) and to know the types of RNA. To comprehend the ultrastructure of the cell nucleus and to associate it with genomic replication and repair mechanisms. To know the mitochondrial genıme, which has a separate genetic system from the cell genome and associate it with the ultrastructure of mitochondria. To comprehend biochemical properties of enzymes and lipids and explain lipid metabolism.
3-To know the mechanism and control of trancription and translation in the cell. To comprehend active and inactive synthesis areas in nucleolus organelle where RNA synthesis from DNA is performed. To comprehend epgenetics and epigenome. To understand DNA and RNA sequencing and discuss its use in biotechnology, forensic medicine and medical diagnosis. To learn about genetic treatments in diseases.
4-To know intracellular traffic and signals. To comprehend the organization formed by cytoskeleton and adhesion molecules. To identify histological and chemical elements of tissues. To get information about physiology. To associate it with the laws of physics. To understand the effects of mutagens, characteristics of cell aging. To understand molecular controls in the cell cycle.
5-To know the mechanism and morphology of the division of somatic and reproductive cells. To understand the stages of division, reproduction and maturation of female and male reproductive cells. To know the "Mendelian principles of inheritance" in the phenomenon of passing hereditary knowledge from mother and father to the next generation. To know the stages of fertilization. To know how the transfer of inheritance with autosomal and sex chromosomes. To know the placement of the embryo in the uterus (implantation). To know prenatal genetic diagnosis (prenatal diagnosis).
Mode of Delivery: Face to face

Learning Outcomes

Knowledge (Described as Theoritical and/or Factual Knowledge.)
  1) Knows medical terminology and comprehend the molecular basis of life.
  2) Distinguishes between chemical structures and has knowledge about chemical bonds and energy.
  3) Defines nucleic acids in the basic components of molecular structure in a living organism. Knows cell tissue preparation methods and types of microscopes.
  4) Knows the basic terms and concepts of human anatomy.
  5) Knows all the organelles of the cell at the level of electron microscopy and associates them with genomic processes. Knows the transcription mechanisms of RNA from DNA.
  6) Comprehends intracellular enzyme and lipid metabolism and knows organelles involved in metabolism.
  7) Knows the chemistry of intracellular free radicals and antioxidants. Knows intracellular macromolecular synthesis pathways and control mechanisms.
  8) Comprehends the effects of physiological stimulation and its relations with the laws of physics. Kows bioelectrical potentials.
  9) Knows the working mechanisms of the hematopoietic system.
  10) Knows the principles of heredity of Mendel.Knows the mechanism and morphology of the division of somatic and reproductive cells.
  11) Discusses the regulation of the biological system. Lists the intracellular location of gene control mechanisms at the ultrastructural level.
  12) Knows the chemical structure and synthesis mechanisms of macromolecules. Lists antioxidants.
Skills (Describe as Cognitive and/or Practical Skills.)
  1) Establishes the relationship between molecule-cell-organelle - gene regulation.
  2) Gives information about anatomical features of body cavities and vascular nerves of limbs.Can list the skull bones, limb joints and bones.
  3) Gives information about the basics of reproductive biology. Transmits information about harmful substances and genetic diagnosis that are active in reproduction.
Competences (Described as "Ability of the learner to apply knowledge and skills autonomously with responsibility", "Learning to learn"," Communication and social" and "Field specific" competences.)
  1) Gains new information to expand her/his knowledge.
  2) Exhibits the ability to be productive and questioning.
  3) Can work independently and take responsibility.

Course Topics

Week Subject
Related Preparation Pekiştirme
1) COMMITTEE-1 ANATOMY: Introduction to Anatomy; BIOCHEMISTRY: Introduction To Organic Chemistry; MEDICAL BIOLOGY and GENETIC: Molecular Evolution Beginning of Life; HISTOLOGY: What is histology? Preparation Methods in Histology; PHYSIOLOGY: Introduction to Physiology and Homeostasis; BIOPHYSICS:Radiation and its Characteristics (Nature of Light, Atomic Structure, Basic Interactions, Nuclear Force Concept).
2) COMMITTEE-1 ANATOMY: Anatomy Terminology; BIOCHEMISTRY: Aliphatic compounds 1 and 2; MEDICAL BIOLOGY and GENETIC: Evolution Theories; HISTOLOGY: Types of Microscopes; BIOPHYSICS: Nuclear Reactions (Fission and Fusion Reactions).
3) COMMİTTEE-1 ANATOMY: Axes; BIOCHEMISTRY: Aromatic compounds 1 and 2; MEDICAL BIOLOGY and GENETIC: Bonds in living organisms and energy concept-Impact of Bond formation on Living Organisms; HISTOLOGY: Transition to Embryology; BIOPHYSICS:Energy Released as a Result of Nuclear Decay.
4) COMMİTTEE-1 ANATOMY: Planes; BIOCHEMISTRY: Heterocyclic compounds, Natural substances; MEDICAL BIOLOGY and GENETIC: Meiosis and gametogenesis; HISTOLOGY: Meiosis and gametogenesis; BIOPHYSICS:Energy Released as a Result of Nuclear Decay.
5) COMMITTEE-2 BIOCHEMISTRY: Definition of Biochemistry, its importance in Medicine and Dentistry; MEDICAL BIOLOGY and GENETIC: Cell Structure Different Membrane; HISTOLOGY: Cell membrane-Microvillus-Cillia-Bonds; BIOPHYSICS: Interaction of radiation with matter.
6) COMMITTEE-2 BIOCHEMISTRY: Water in the Body and Its Metabolism; MEDICAL BIOLOGY and GENETIC: Cell Structure Different Membrane; HISTOLOGY: Cell membrane-Microvillus-Cillia-Bonds; BIOPHYSICS: Interaction of radiation with matter.
7) COMMITTEE-2 BIOCHEMISTRY: pH and Buffers; MEDICAL BIOLOGY and GENETIC: DNA-RNA structure and differences - RNA types; HISTOLOGY: Ribosome-Microtubule; PHYSIOLOGY: Cell membrane transition and secondary messenger system; BIOPHYSICS: X-Ray Imaging Methods.
8) COMMITTEE-2 BIOCHEMISTRY: Enzymes-1; MEDICAL BIOLOGY and GENETIC: Properties of genetic material, DNA replication, DNA repair systems, Chromatin structure; HISTOLOGY: Nucleus and chromosomes; BIOPHYSICS: X-Ray Device Structure.
9) COMMITTEE-2 BIOCHEMISTRY: Enzymes-2; MEDICAL BIOLOGY and GENETIC: Mitochondrial genome-aging - mitochondrial diseases; HISTOLOGY: Mitochondria; BIOPHYSICS: Structure of Computed Tomography Device.
10) COMMITTEE-3 BIOCHEMISTRY: Biological Oxidations; MEDICAL BIOLOGY and GENETIC: RNA transcription mechanism, RNA function; HISTOLOGY: Nucleolus; BIOPHYSICS: Structure of Magnetic Resonance Device.
11) COMMITTEE-3 BIOCHEMISTRY: Free radicals, Antioxidants, Antioxidant Nutrients; MEDICAL BIOLOGY and GENETIC: Genetic code, protein synthesis; BIOPHYSICS: Ultrasonography.
12) COMMITTEE-3 BIOCHEMISTRY: Nucleic Acids and Protein Synthesis; MEDICAL BIOLOGY and GENETIC: Control mechanisms of gene expression (at transcription and translation level; BIOPHYSICS: Laser Physics-1.
13) COMMITTEE-3 BIOCHEMISTRY: Hormones and Biochemical Mechanisms of Action; MEDICAL BIOLOGY and GENETIC: Epigenetics and Epigenome; BIOPHYSICS: Laser Physics-2.
14) COMMITTEE-3 BIOCHEMISTRY: Lipids and their Biological Importance; MEDICAL BIOLOGY and GENETIC: DNA and RNA sequencing with DNA replication/ Gene Therapy.
15) COMMITTEE-4 BIOCHEMISTRY: Carbohydrates and their biological importance; MEDICAL BIOLOGY and GENETIC: Cell signal transduction 1: signal transduction and short-term cellular responses; HISTOLOGY: Connective Tissue 1.
16) COMMITTEE-4 BIOCHEMISTRY: Glycosaminoglycans-Proteoglycans; MEDICAL BIOLOGY and GENETIC: HÜCRE SİNYAL İLETİMİ II: Cell signal transduction-2 :signaling pathways that control gene activity; HISTOLOGY: Connective Tissue 2.
17) COMMITTEE-4 BIOCHEMISTRY: Amino acids and proteins; MEDICAL BIOLOGY and GENETIC: Adhesion molecules; HISTOLOGY: Epithelial Tissue.
18) COMMITTEE-4 ANATOMY: Bones of the Skull and Vertebral Column; BIOCHEMISTRY: Biochemistry of Connective Tissue; MEDICAL BIOLOGY and GENETIC: Cytoskeletal proteins; HISTOLOGY: Glandular Epithelium.
19) COMMITTEE-4 ANATOMY: Bones of the upper limb; BIOCHEMISTRY: Bone Biochemistry; MEDICAL BIOLOGY and GENETIC: Intracellular Protein Traffic, Protein Destruction (Proteasome Chaperone); HISTOLOGY: Cartilage Tissue.
20) COMMITTEE-4 ANATOMY: Joints of the upper limb; MEDICAL BIOLOGY and GENETIC: Mutagenic effects; HISTOLOGY: Bone Tissue.
21) COMMITTEE-4 ANATOMY: Bones of the lower limb; MEDICAL BIOLOGY and GENETIC: Cell aging: apoptosis, necrosis mechanism; HISTOLOGY: Hematopoiesis; PHYSIOLOGY: Hematopoietic System.
22) COMMITTEE-4 ANATOMY: Joints of the lower limb; HISTOLOGY: Nerve Tissue; PHYSIOLOGY: Excitable Tissues and Action Potential.
23) COMMITTEE-4 ANATOMY: Muscles of the lower limb; MEDICAL BIOLOGY and GENETIC: Cell Cycle - Cell Division - Meiosis-Mitosis; HISTOLOGY: Muscle Tissue, Cardiac Muscle; PHYSIOLOGY: Muscle Physiology; BIOPHYSICS: Laws of Motion.
24) COMMITTEE-4 MEDICAL BIOLOGY and GENETIC: Cell Cycle - Checkpoints-Cyclins; HISTOLOGY: Gametogenesis.
25) COMMITTEE-5 ANATOMY: Thorax and abdomen veins and nerves; BIOCHEMISTRY: Carbohydrate Metabolism 1 and 2; MEDICAL BIOLOGY and GENETIC: Mendel Genetics-Family Tree Pedigree; HISTOLOGY: Spermatogenesis.
26) COMMITTEE-5 ANATOMY: Veins and nerves of the Pelvis; BIOCHEMISTRY: Protein Metabolism; MEDICAL BIOLOGY and GENETIC: Non-Mendelian Genetics; HISTOLOGY: Fertilization.
27) COMMITTEE-5 ANATOMY: Veins and nerves of the upper limb; BIOCHEMISTRY: Lipid Metabolism 1 and 2 MEDICAL BIOLOGY and GENETIC: Autosomal and Sex chromosome-related diseases; HISTOLOGY: Implantation.
28) COMMITTEE-5 ANATOMY: Veins and nerves of the lower limb; BIOCHEMISTRY: Porphyrin Compounds-Bile Pigments; MEDICAL BIOLOGY and GENETIC: Prenatal Diagnosis; HISTOLOGY: Teratogens.
References: Anatomi:
**Arifoğlu, Y. (2021). Her Yönüyle ANATOMİ 3. BASKI.
**FH, N. (2010). İnsan Anatomisi Atlası (6. Baskı). Cumhur M.(Edt), Nobel Tıp Kitabevi, İstanbul.

Biyokimya:
**Stoker, H. S. (2015). General, organic, and biological chemistry. Cengage Learning.
**McMurry, J., Castellion, M. E., Ballantine, D. S., Hoeger, C. A., & Peterson, V. E. (1996). Fundamentals of general, organic, and biological chemistry.
**Wictor W. Rodwell, D. A. B., Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil. (2019). Harper'ın Resimli Biyokimyası (31 ed.). Güneş Tıp Kitabevi.
**Gürdöl, F. (2021). Tıbbi Biyokimya (5 ed.). Nobel Tıp Kitapevi.

Tıbbi Biyoloji ve Genetik:
**Geçkil, H., Özmen, M., & Yeşilada, Ö. (2011). Moleküler Hücre Biyolojisi. Palmae yayıncılık.
**Klug, W. S., Cummings, M. R., Spencer, C. A., & Öner, C. (2011). Genetik kavramlar. Palme Yayıncılık.
**Campbell, N. A. (2015). Campbell biyoloji. Palme Yayıncılık.
**Allison, L. (2014). Temel Moleküler Biyoloji. Palme Yayınevi.
**Nalini Chandar, S. V. (2012). Lippincott's Hücre ve Moleküler Biyoloji. Nobel Tıp Kitapevi.
Histoloji ve Embriyoloji:
**Junqueira, L. C. U., Carneiro, J., Aytekin, Y., & Solakoğlu, S. (2009). Temel histoloji: text & atlas. Nobel Tıp Kitabevleri.
**Mescher, A. (2015). Junqueira's Temel Histoloji Atlas Kitap. İstanbul: Nobel Tıp Kitabevleri Tic. Ltd. Şti.
**Demir, R. (2006). Histoloji ve Hücre Biyolojisi: Patolojiye Giriş. Palme Yayıncılık.
**Ross, M., & Pavlina, W. (2014). Histoloji Konu Anlatımı ve Atlas (6. Baskı). B. Baykal (Çev.), Ankara: Palme Yayıncılık.
**Yüncü, P. D. M. (2016). Genel Histoloji ve Genel Embriyoloj. Çukurova Nobel Tıp Kitapevi.
**Can, A. (2018). Yaşam Bilimlerinde A’dan Z’ye Mikroskopi. Ankara Nobel Tıp Kitapevi.

Fizyoloji:
**Hall, J. (2016). Guyton ve Hall tıbbi fizyoloji (13. Baskı). Ankara: Güneş Tıp Kitabevleri.
**Widmaier, E. P., Raff, H., & Strang, K. T. (2014). Vander insan fizyolojisi: vücut fonksiyon mekanizmaları. Güneş Tıp Kitabevleri.

Biyofizik:
**Turner, J. E. (2008). Atoms, radiation, and radiation protection. John Wiley & Sons.
**Ahmet Fatih KOCAER, B. C., Birnur YILMAZ, Ceren ÖZTÜRK, Fatih BEŞEVLİ, Halil BOZKAYA, Hüseyin Ozan TEKİN, Miraç KAMIŞLIOĞLU, Murat DÜNDAR, Orhan OYAR, Türkan UZ İKİZCELİ. (2018). X Işınları Görüntüleme Teknikler. Kongre Kitapevi.
**Del Guerra, A. (2004). Ionizing radiation detectors for medical imaging. World scientific.
**Hüseyin OZAN TEKİN, M. D., Ali SALAR, Barış CAVLI, Mustafa Cantay GÖK. (2020). Manyetik Rezonans Görüntüleme Teknikleri ve Temel Prensipler. Kongre Kitapevi.
**Aydın, R. (2016). Lazer ve Tıp Uygulamaları. ODTÜ Yayıncılık.
**Jewett, J. W., & Serway, R. (2008). Physics for scientists and engineers with modern physics. Vectors, 1, 2.

Ders - Program Öğrenme Kazanım İlişkisi

No Effect 1 Lowest 2 Average 3 Highest
       
Ders Öğrenme Kazanımları

1

2

3

4

5

6

7

8

9

10

12

13

11

14

15

16

17

18

Program Outcomes
1) The normal, abnormal and pathological structures and functions related to oral and dental health in detail. 1 3
2) The basic and up-to-date knowledge required by the dentistry profession. 3 2 3 1 1 2 2 2 1
3) The integration of knowledge from different disciplines in the clinic phase and to put their knowledge into practice.
4) Applying knowledge in a holistic approach in professional practice. 1 2 1 3 3
5) Evaluating the accuracy, reliability and validity of the knowledge. 3 3
6) Showing a systematic approach to diagnosis.
7) Delivering optimum care for patients with correct diagnosis and treatment plan.
8) Conduct a clinical study or a project individually in the field of dentistry.
9) Take responsibility for the use of all technological tools used in dental treatment. 1 3
10) Take responsibility in planning and management of either routine applications or complex and unforeseen problems. 3 3
11) Participate in national and international academic studies by adopting lifelong learning, share and compare written, verbal and visual information with their colleagues. 3
12) Follow the evidence-based dentistry knowledge and use the up-to-date knowledge in professional practice within the framework of national values and country facts for the benefit of the society. 1 3 3
13) Use the information and communication technologies at the level required by the field of dentistry. 1
14) Take part and responsibilities in preventive programs at the social level, and ensure the protection and development of health by applying modern treatment methods with an approach that is patient-oriented, in line with human rights and compatible with the health economy. 2 2
15) Organize and implement social responsibility projects and activities. 2 2
16) Have proficiency in one foreign language at minimum B1 Level according to European Language Portfolio Global Scale, have written and oral communication skills and follow the developments in their field. 2
17) Apply the principle of entrepreneurship, business practices and processes with innovative technology in dentistry.
18) Are aware of the significance of ethical rules and legal responsibilities required by the profession. 3
19) Have knowledge about teamwork, leadership, risk management, patient safety, universality of social rights, social justice, quality management, personal development, environmental protection, occupational health and safety in the delivery and management of oral and dental healthcare services.
20) Implement the required practices in the clinic management, auxiliary personnel training, prevention methods from occupational diseases.

Course Teaching, Learning Methods

Q & A
Case Problem Solving/ Drama- Role/ Case Management
Laboratory
Quantitative Problem Solving
Fieldwork
Group Study / Assignment
Individual Assignment
WEB-based Learning
Internship
Practice in Field
Project Preparation
Report Writing
Seminar
Supervision
Social Activity
Occupational Activity
Occupational Trip
Application (Modelling, Design, Model, Simulation, Experiment et.)
Reading
Thesis Preparation
Field Study
Student Club and Council Activities
Other
Logbook
Interview and Oral Conversation
Research
Watching a movie
Bibliography preparation
Oral, inscribed and visual knowledge production
Taking photographs
Sketching
Mapping and marking
Reading maps
Copying textures
Creating a library of materials
Presentation

Evaluation System

Semester Requirements Number of Activities Level of Contribution
Attendance % 0
Laboratory % 0
Application % 0
Practice Exam % 0
Quizzes % 0
Homework Assignments % 0
Presentation % 0
Project % 0
Special Course Internship (Work Placement) % 0
Field Study % 0
Article Critical % 0
Article Writing % 0
Module Group Study % 0
Brainstorming % 0
Role Playing + Dramatizing % 0
Out of Class Study % 0
Preliminary Work, Reinforcement % 0
Application Repetition etc. % 0
Homework (reading, writing, watching movies, etc.) % 0
Project Preparation + Presentation % 0
Report Preparation + Presentation % 0
Presentation / Seminar Preparation + Presenting % 0
Oral examination % 0
Midterms 5 % 40
Final 1 % 60
Report Submission % 0
Bütünleme % 0
Kanaat Notu % 0
Committee % 0
Yazma Ödev Dosyası % 0
Portfolio % 0
Take-Home Exam % 0
Logbook % 0
Discussion % 0
Participation % 0
total % 100
PERCENTAGE OF SEMESTER WORK % 40
PERCENTAGE OF FINAL WORK % 60
total % 100

Calculation of Workload and ECTS Credits

Activities Number of Activities Workload
Course Hours 28 168
Laboratory 28 84
Application
Practice Exam
Special Course Internship (Work Placement)
Field Work
Study Hours Out of Class 28 280
Article Critical
Article Writing
Module Group Study
Brainstorming
Role Playing + Dramatizing
Out-of-Class Study (Pre-study, Reinforcement, Practice Review, etc.)
Homework (reading, writing, watching movies, etc.) 14 14
Project Preparation + Presentation
Report Preparation + Presentation
Presentation / Seminar Preparation + Presenting
Oral examination
Preparing for Midterm Exams 5 80
MIDTERM EXAM (Visa) 5 5
Preparing for the General Exam 2 30
GENERAL EXAM (Final) 1 1
Participation
Discussion
Portfolio
Take-Home Exam
Logbook
Total Workload 662
ECTS (30 saat = 1 AKTS ) 22